PhD Student - Generic Physiologically Based (PBK) Models in Toxicology

The Fraunhofer Institute for Toxicology and Experimental Medicine ITEM is one of 75 institutes and research institutions of the Fraunhofer-Gesellschaft, the world’s leading applied research organization. Protecting man from health hazards in our industrialized world and contributing to the development of novel therapeutic approaches are the aims Fraunhofer ITEM is pursuing with its contract research. With a focus on respiratory research, our R&D portfolio includes three business areas: drug development, chemical safety, and translational medical technology.

With approximately 350 employees in Hanover and Regensburg, the institute collaborates on projects with industry, service providers, and universities for the benefit of the economy and society. For 40 years, we have been pursuing our vision »Pioneers for sustainable health« at our founding location in Hanover.

Are generic physiologically based (PBK) models your area of interest?

Then we are offering you an exciting opportunity to join us as soon as possible as a PhD Student focusing on the d evelopment of generic physiologically based kinetic (PBK) models in the » In Silico Toxicology « department at our Hanover location.

Be part of change

As part of your doctoral research on the topic “Focus on the development of generic physiologically based kinetic (PBK) models for toxicology,” your responsibilities will include:

• Further development of an existing PBK model at Fraunhofer ITEM
• Integration of in vitro ADME parameters into the PBK model and analysis of the resulting uncertainties
• Familiarization with the principles of exposure modeling
• Integration of both modules

What you contribute

• A completed university degree in computer science or a comparable science-related field, such as mathematics or bioinformatics
• Interest in mathematical concepts, bioinformatics, as well as mass transport and mass balances
• Proficiency in at least one of the common programming languages or software programs (e.g., Python, MATLAB, Mathematica, R, KNIME, etc.)
• Experience working with common database formats is an advantage
• Good written and spoken English skills are advantageous, as the work is part of an EU project

What we offer

• Cutting-edge research : Join a dedicated team of experienced scientists and work on international research projects
• Balance : With us, you have the opportunity to organize your work hours flexibly and work partly remotely from home
• Collaboration : Whether at Lunch Roulette with randomly matched colleagues or at WissensZeit with inspiring talks — we encourage exchange and networking
• Development : We not only take research to the next level, but also your development — with a wide range of training opportunities and conferences
• Time off : Look forward to 30 days of vacation per year, plus days off for Christmas and New Year’s Eve
• Getting here : Whether by car, bike, or public transit—with free parking, charging stations, bike racks, and a subsidy for the Deutschlandticket
• Company restaurant : Enjoy your lunch break in our company restaurant at discounted prices
• Corporate Benefits: Enjoy attractive discounts on numerous top brands

• Remuneration is 65% of an TVöD pay group 13 (dependent on qualifications).
• The position is initially limited to 2 years – however, we are looking towards long-term employment.
• The weekly working time is 39 hours.

We value and promote the diversity of our employees' skills and therefore welcome all applications – regardless of age, gender, nationality, ethnic and social origin, religion, ideology, disability, sexual orientation and identity. Severely disabled persons are given preference in the event of equal suitability. Our tasks are diverse and adaptable – for applicants with disabilities, we work together to find solutions that best promote their abilities.

With its focus on developing key technologies that are vital for the future and enabling the commercial utilization of this work by business and industry, Fraunhofer plays a central role in the innovation process. As a pioneer and catalyst for groundbreaking developments and scientific excellence, Fraunhofer helps shape society now and in the future.

Ready for a change? Then apply now and make a difference! Once we have received your online application, you will receive an automatic confirmation of receipt. We will then get back to you as soon as possible and let you know what happens next.

If you have any questions about this position, please feel free to contact:

Dr. Sylvia Escher
Division Director of Safety Assessment and Toxicology & Head of Department of In-silico Toxicology
Phone +49 511 5350-330

Fraunhofer Institute for Toxicology and Experimental Medicine ITEM

Requisition Number: 84246